中国高校科技期刊研究会第9次会员代表大会在北京召开，中宣部出版局副局长张怀海、教育部科学技术与信息化司一级巡视员张国辉等领导出席会议并发表..
英文简介：The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.Some specific areas that are appropriate include the following: * Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools. * Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication. *Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds. * Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition. *Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge. * Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules. * Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds. This may include design, synthesis, and evaluation of novel types of prodrugs. * Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.中文简介：（来自Google、百度翻译）《药物化学杂志》发表的研究有助于理解分子结构与生物活性或作用方式之间的关系。 一些适当的特定领域包括: * 设计，合成，以及用作药理工具的新型生物活性化合物，诊断剂或标记配体的生物学评估。 * 报道系列的分子修饰可显着提高对其构效关系 (SAR) 的理解。现有系列的常规扩展，如果不使用新颖的化学或生物学方法，或者没有显著增加对该系列SAR的基本理解，通常不会被接受出版。 * 结构生物学研究 (x射线，核磁共振，等) 的相关配体和靶标，目的是研究生物活性化合物作用中的分子识别过程。 * 分子生物学研究 (例如，对大分子靶标进行定点诱变)，从而提高了对分子识别的理解。 * 计算研究提供了对当前普遍感兴趣的化合物系列SAR的新见解，或对随后推进药物化学知识的其他可用数据的分析。 * 基本新颖的计算具有鉴定价值的化学方法，生物活性分子的优化或目标相互作用分析。 * 分子结构对生物活性化合物的分布，药代动力学和代谢转化的影响。这可能包括新型前药的设计，合成和评估。 * 新颖的方法学可广泛应用于药物化学，但前提是该方法已在相关分子上进行了测试。
